By Anthony R. Rees
The Antibody Molecule follows the intense trip of the medics and scientists who formed the process clinical advances within the box of immunology. one of many oldest of the clinical sciences, immunology has a historical past that has visible chemists, physicists and biologists alike looking to get to the bottom of the main advanced process within the human physique outdoor the mind. This e-book charts its interesting background, from the genetic foundation of antibody variety, throughout the realizing of the mechanism through which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as healing structures to regard melanoma, irritation and allergy.
Tracing the advancements in immunology in chronological order, Professor Antony R. Rees offers the historic contexts of the sessions in wealthy element, bringing them to lifestyles with rates and illustrations. This interesting e-book examines the literature of the time, turning issues, and controversies. A needs to learn for immunologists and existence scientists, in addition to historians of technological know-how and drugs.
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Extra info for The Antibody Molecule: From antitoxins to therapeutic antibodies
38: 362–76. 36. J. (1975). ’ Bacteriol. , 39: 54–85. 37. Marquart, M. (1949). Paul Ehrlich. London: Heinemann. 38. Ehrlich. P. (1900). ’ Royal Society Croonian Lecture, in Roy. Soc. , 66: 437. 39. Kaplan, A. (1964). The Conduct of Enquiry: Methodology for Behavioural Science. 279. 40. Anonymous (1839). A. (2003). ’Microbiology, 149: 557–67. 41. M. H. (1995). Species and Specificity. Cambridge: Cambridge University Press, pp. 123–35. 33 Chapter 3 Structural chemistry: Locks, keys, and colloids Landsteiner and post-Ehrlich developments The breakthroughs of the Koch, von Behring, Pasteur, and Ehrlich era, though dramatic in relation to the status quo of contemporary chemistry and biology, were yet to explain the molecular basis of antibody action on toxins and viruses.
41. M. H. (1995). Species and Specificity. Cambridge: Cambridge University Press, pp. 123–35. 33 Chapter 3 Structural chemistry: Locks, keys, and colloids Landsteiner and post-Ehrlich developments The breakthroughs of the Koch, von Behring, Pasteur, and Ehrlich era, though dramatic in relation to the status quo of contemporary chemistry and biology, were yet to explain the molecular basis of antibody action on toxins and viruses. While immunology made giant strides with its vaccine and immune serum advances, structural chemistry was uncertain about the exact nature of the large molecules that mediated those immunological effects.
In the Straights of Messina, a Russian zoologist and prodigy, Elie Metchnikoff, was on course to take the scientific establishment into yet more controversy. It was while in his marine laboratory that he began the work that would seek to question current thinking on the role of phagocytic cells in the blood. One of his target organisms was the water flea Daphnia, a small and more or less transparent crustacean. Metchnikoff observed over many hours at a time the course of infection of Daphnia by a fungus he named Monospora bicuspidata (he was unsure if it was a yeast or a fungus going through a yeast-like stage).
The Antibody Molecule: From antitoxins to therapeutic antibodies by Anthony R. Rees