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Kaplan's Kaplan MCAT Biology Review PDF

By Kaplan

ISBN-10: 1607146436

ISBN-13: 9781607146438

A full-color advisor that includes all-new, whole attempt special biology assessment for the MCAT, Kaplan MCAT Biology contains over 500 perform questions (hundreds greater than the contest) and 3 full-length biology perform sections. professional statement and guideline from a most sensible Kaplan instructor contains assistance, tips, and attempt services. vivid illustrations, charts, and graphs from the pages of Scientific American, make this advisor a compelling resource of MCAT prep.

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The proteins that comprise many of these subfamilies utilize the energy from ATP hydrolysis to transport along microtubules. However, at least 2 kinesin subfamilies, the kinesin-13s and kinesin-14s, contain motors with microtubule-destabilizing activity (6–8). Detailed mechanistic studies of the microtubule-destabilizing activity exhibited by these motors have significantly contributed to our understanding of their cellular functions. In this chapter, we discuss assays for measuring the microtubule-destabilizing activity of kinesins both in a purified system and within the context of mammalian cells.

16. II. Anal. Biochem. 89, 297–303. A. (1979) An improved 17. assay for nanomole amounts of inorganic phosphate. Anal. Biochem. 100, 95–97. S. N. (1999) A plant calmodulin-binding motor is part 18. kinesin and part myosin. Bioinformatics 15, 1055–1057. N. (1999) Interaction of 19. a kinesin-like protein with calmodulin isoforms from Arabidopsis. J. Biol. Chem. 274, 31727–31733. indd 36 3/20/2007 3:07:26 PM 3 In Vitro and In Vivo Analysis of Microtubule-Destabilizing Kinesins Jason Stumpff, Jeremy Cooper, Sarah Domnitz, Ayana T.

Protein phosphorylation is the most common posttranslational modification in mammalian cells, regulating critical cellular processes that include cell division, differentiation, growth, and cell–cell signaling as well as fast axonal transport (FAT). Evidence has accumulated that kinesin-1 phosphorylation plays a key regulatory role in kinesin-based FAT. Multiple kinase and phosphatase activities with the ability to regulate kinesin-1 function and FAT have been identified. Moreover, additional pathways are likely to exist for regulating FAT through reversible phosphorylation/dephosphorylation of specific motor protein subunits.

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Kaplan MCAT Biology Review by Kaplan


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