By Jeffrey O. Hollinger DDS, PhD (auth.), Jay R. Lieberman MD, Gary E. Friedlaender MD (eds.)
With their quick evolution, either the advance of recombinant proteins and the appliance of gene remedy options promise to revolutionize the remedy of bone and cartilage fix. In Bone Regeneration and service: Biology and medical functions, a panel of prime orthopedic and craniofacial surgeons and researchers comprehensively studies the biology of bone formation and service, the elemental technological know-how of autologous bone graft, allograft, bone substitutes, and development components, and explores their scientific software in sufferers with bone fix difficulties.
Authoritative and cutting-edge, Bone Regeneration and service: Biology and scientific functions won't basically stimulate investigators to pursue a deeper figuring out of ways most sensible to harness the body's inherent regenerative power, but additionally significantly improve the day by day care of patients.
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Extra resources for Bone Regeneration and Repair: Biology and Clinical Applications
It exists first as an inactive precursor peptide that is activated by the acidic conditions of the callus or proteases and becomes the most potent chemoattractant identified for macrophages (34–37). TGF-b also has many other roles, including promoting angiogenesis, which is essential for orderly fracture repair (10); stimulating bone formation by inducing differentiation of periosteal mesenchymal cells into chondroblasts and osteoblasts (38–40); regulating cartilage matrix calcification; and stimulating osteoblast activity and intraosseus wound regeneration (13, 41,42).
Et al. (1989) Neutral protein-degrading enzymes in experimental fracture callus: a preliminary report. J. Orthop. Res. 7(6), 792–805. 18. Brighton, C. T. and Hunt, R. M. (1986) Histochemical localization of calcium in the fracture callus with potassium pyroantimonate. Possible role of chondrocyte mitochondrial calcium in callus calcification. J. Bone Joint Surg. Am. 68(5), 703–715. 19. Wendeberg, B. (1961) Mineral metabolism of fractures of the tibia in man studied with external counting of strontium 85.
M. (1989) The biology of fracture healing. An overview for clinicians. Part I. Clin. Orthop. 248, 283–293. 5. McKibbin, B. (1978) The biology of fracture healing in long bones. J. Bone Joint Surg. Br. 60B(2), 150–162. 6. White, A. A. , Punjabi, M. , and Southwick, W. O. (1977) The four biomechanical stages of fracture healing. J. Bone Joint Surg. 59A, 188. 7. Thomas, T. A. (1998) The cell and molecular biology of fracture healing. Clinical Orthopaedics & Related Research. Fracture Healing Enhancement 1(355 Suppl), S7–S21.
Bone Regeneration and Repair: Biology and Clinical Applications by Jeffrey O. Hollinger DDS, PhD (auth.), Jay R. Lieberman MD, Gary E. Friedlaender MD (eds.)