By Johan N.M. Heersche and J. A. Kanis (Eds.)
The purpose in placing jointly this seventh quantity of the Bone and Mineral learn sequence has been to offer top of the range, updated stories and in-depth analyses in parts the place advancements are, or probably might be, of significant curiosity to the Bone and Mineral examine neighborhood. The excessive ordinary already validated within the past six volumes of this sequence (under course of Dr. William A. Peck) has been maintained. There has een a few outstanding growth made inside a few components of bone and mineral study, while in different parts a sluggish and slow accumulation of information has ended in elevated perception, in order good as together with experiences in either components, the chapters emphasize the advance of latest recommendations. The bankruptcy matters coated are as follows
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Extra resources for Bone and Mineral Research. A Regular Survey of Developments in the Field of Bone and Mineral Metabolism
The amount of serum bone gla-protein increases 12 h after administration of l , 2 5 - ( O H ) 2 D in both young and old rats (Price, 1985). l , 2 5 - ( O H ) 2 D modifies both alkaline phosphatase activity and collagen formation in vitro. , 1981), depending upon the differentiation status of the cells (Rodan and Rodan, 1984). C T : T h e hormone was discovered by the rapid hypocalcaemia elicited by its ad ministration to the rat. T h e mechanisms of this effect were assessed by Milhaud et al. (1965b) on the basis of calcium kinetics using 4 5 Ca performed in vivo.
1984). As b H A is a stable form with regard to E C F , bone résorption requires the production of a local milieu. Classically, it is assumed that bone mineral is released first and this is followed by matrix degradation. , 1985) or via the activity of carbonic anhydrase (Kenny, 1985). At the acid p H reported for osteoclast résorption fluid, Neuman et al. (1987) suggest that the resorbing mineral may revert to precursor form or cluster, thus contributing to the maintenance of metastable Ca-P forms at the bone surface.
Around the lacunae and canaliculi, there is a thin layer of non mineralized matrix which separates the cellular processes from the mineralized wall. Most of the free bone surfaces in rapidly growing young animals are either forming or resorbing. In adult man, 8 0 % of the free bone surface is quiescent and covered by bone-lining cells (Parfitt, 1984). , 1985). Osteocytes are very frequent and their distribution bears no relationship to vascular canals. , 1982). Immature bone is normal ly replaced by lamellar bone through internal 'remodelling'.
Bone and Mineral Research. A Regular Survey of Developments in the Field of Bone and Mineral Metabolism by Johan N.M. Heersche and J. A. Kanis (Eds.)