Sio 2 Books > Biology > Download PDF by Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H.: Biology of Growth Factors: Molecular Biology, Oncogenes,

Download PDF by Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H.: Biology of Growth Factors: Molecular Biology, Oncogenes,

By Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)

ISBN-10: 1475719809

ISBN-13: 9781475719802

ISBN-10: 1475719825

ISBN-13: 9781475719826

Growth components are elaborated to regulate the expansion of cells in such physiological procedures as wound therapeutic, tissue regeneration and the immune reaction. irregular construction of those development components, their receptors or intracellular med!ators in their motion could lead on to ailment states together with oncogenesis. This quantity will specialise in interesting advancements in defining the correct molecular lesions that allow the conversion of managed proliferative signs to neoplasia, at the attainable involvement of progress components within the improvement of blood vessel ailments as visible in diabetes and atherosclerosis, at the altered immune surveillance that ends up in autoimmunity and at the primary mechanisms through which development components sign their goal cells. we think that the contents of this quantity may also help advertise realizing of the function of those basic organic methods and their changes in a large choice of illness states and stimulate new investi­ gations during this vital region of biomedical study. The Editors v CONTENTS views at the keep an eye on OF progress AND DIFFERENTIATION views at the Biology of development elements . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived development issue- Its position in well-being and illness. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine R. Ross and E. W. Raines Molecular and Developmental Biology facets of Fibroblast progress issue. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical houses of Human Angiogenin. . . . . . . . . . forty-one B. L. Vallee and J. F. Riordan progress issue - ONCOGENE RELATIONSHIPS constitution - functionality Relationships in mobile and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . fifty five T. Pawson. P. Greer, M. Moran, K.

Show description

Read Online or Download Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications PDF

Best biology books

Glossary of Molecular Biology Terminology (From: Hematology - download pdf or read online

This thesaurus is designed lo aid ihe reader with the terminology of molecular biology. every year, the thesaurus should be accelerated to incorporate new phrases brought within the schooling software. the elemental terminology of molecular biology can be integrated. The word list is split into numerous normal sections.

Download PDF by Cooper C., Packer N.: Amino Acid Analysis Protocols (Methods in Molecular Biology

Proteome platforms Ltd, North Ryde, Australia. Describes numerous amino acid research strategies and the way every one procedure can be utilized to respond to particular biologic questions.

Read e-book online Target Discovery and Validation Reviews and Protocols, Vol PDF

Aim Discovery and Validation: reports and Protocols, Volumes 1 and a pair of overview the main innovative and present equipment for drug objective discovery and validation. those volumes discover how contemporary development in figuring out the molecular mechanisms of human pathology is impacting drug aim discovery within the laboratory and in actual therapeutics, particularly for cancers and autoimmune issues.

Download e-book for kindle: Trends in the Biology of Fermentations for Fuels and by Alexander Hollaender (auth.), Alexander Hollaender, Robert

The growing to be crisis approximately the place power wealthy chemical compounds for the long run will come from has inspired a resurgence of curiosity within the prospects of microbial fermentations to aid in assembly anti­ cipated calls for for fuels and chemical substances. whereas a lot cognizance has been given lately to the early deployment of alcohol construction crops and related at the moment to be had applied sciences, the aptitude destiny advancements have acquired less awareness.

Extra info for Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications

Example text

1978). Basic FGF stabilizes the phenotypic expression of cultured cells. (Table 3) (Gospodarowicz, 1985). ,1978). ,1979; Gospodarowicz, 1985). This effect of bFGF on cell differentiation may be due to its ability to control the synthesis and deposition of various extracellular matrix (ECM) components that are known to affect cell surface polarity and gene expression. These include collagen, fibronectin, laminin, and proteoglycans (reviewed in Gospodarowicz and Greenburg,1981). 29 Basic FGF can induce capillary endothelial cells to invade a three-dimensional collagen matrix and to organize themselves to form characteristic tubules that resemble blood capillaries.

This is in close agreement with previous in vitro studies which have shown that FGF had a transforming activity~nd could act as a morphogen, as well as a mitogen, on practically all mesoderm-derived cells studied to date. The FGF capability to induce mesoderm formation in early embryo is also of interest in view of its partial structural homology with the oncogene Int-2 (Dickson and Peters, 1987). , 1986). In lower vertebrates (amphibians) bFGF can promote limb regeneration (Gospodarowicz and Mescher,1981).

1986a,b). Cross-linking of bFGF or aFGF to the BHK-21 cell surface receptor indicates that qualitatively, both mitogens interact with the same two M 145 kD and 125 kD membrane components, which could differ by their aegree of glycosylation. Quantitatively, bFGF appears to display a higher affinity than aFGF for the M =145 kD receptor species, while aFGF displays a higher affinity than bFGF for the M =125 kD receptor species (Neufeld and Gospodarowicz,1986). This couldrhelp in explaining the different biological potencies of bFGF versus aFGF (see below).

Download PDF sample

Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications by Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)


by Edward
4.0

Rated 4.18 of 5 – based on 24 votes