By Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)
Growth components are elaborated to regulate the expansion of cells in such physiological procedures as wound therapeutic, tissue regeneration and the immune reaction. irregular construction of those development components, their receptors or intracellular med!ators in their motion could lead on to ailment states together with oncogenesis. This quantity will specialise in interesting advancements in defining the correct molecular lesions that allow the conversion of managed proliferative signs to neoplasia, at the attainable involvement of progress components within the improvement of blood vessel ailments as visible in diabetes and atherosclerosis, at the altered immune surveillance that ends up in autoimmunity and at the primary mechanisms through which development components sign their goal cells. we think that the contents of this quantity may also help advertise realizing of the function of those basic organic methods and their changes in a large choice of illness states and stimulate new investi gations during this vital region of biomedical study. The Editors v CONTENTS views at the keep an eye on OF progress AND DIFFERENTIATION views at the Biology of development elements . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived development issue- Its position in well-being and illness. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine R. Ross and E. W. Raines Molecular and Developmental Biology facets of Fibroblast progress issue. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical houses of Human Angiogenin. . . . . . . . . . forty-one B. L. Vallee and J. F. Riordan progress issue - ONCOGENE RELATIONSHIPS constitution - functionality Relationships in mobile and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . fifty five T. Pawson. P. Greer, M. Moran, K.
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Extra info for Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications
1978). Basic FGF stabilizes the phenotypic expression of cultured cells. (Table 3) (Gospodarowicz, 1985). ,1978). ,1979; Gospodarowicz, 1985). This effect of bFGF on cell differentiation may be due to its ability to control the synthesis and deposition of various extracellular matrix (ECM) components that are known to affect cell surface polarity and gene expression. These include collagen, fibronectin, laminin, and proteoglycans (reviewed in Gospodarowicz and Greenburg,1981). 29 Basic FGF can induce capillary endothelial cells to invade a three-dimensional collagen matrix and to organize themselves to form characteristic tubules that resemble blood capillaries.
This is in close agreement with previous in vitro studies which have shown that FGF had a transforming activity~nd could act as a morphogen, as well as a mitogen, on practically all mesoderm-derived cells studied to date. The FGF capability to induce mesoderm formation in early embryo is also of interest in view of its partial structural homology with the oncogene Int-2 (Dickson and Peters, 1987). , 1986). In lower vertebrates (amphibians) bFGF can promote limb regeneration (Gospodarowicz and Mescher,1981).
1986a,b). Cross-linking of bFGF or aFGF to the BHK-21 cell surface receptor indicates that qualitatively, both mitogens interact with the same two M 145 kD and 125 kD membrane components, which could differ by their aegree of glycosylation. Quantitatively, bFGF appears to display a higher affinity than aFGF for the M =145 kD receptor species, while aFGF displays a higher affinity than bFGF for the M =125 kD receptor species (Neufeld and Gospodarowicz,1986). This couldrhelp in explaining the different biological potencies of bFGF versus aFGF (see below).
Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications by Irving B. Fritz (auth.), Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, Avrum I. Gotlieb (eds.)