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Bioinformatics : genes, proteins, and computers by Christine Orengo, David Jones, Janet Thornton PDF

By Christine Orengo, David Jones, Janet Thornton

ISBN-10: 1859960545

ISBN-13: 9781859960547

This identify describes the advance and use of computational and mathematical tools for the purchase, archiving, research and interpretation of organic aspect. It information conventional techniques, in addition to contemporary technological advances. Molecular evolution / Sylvia Nagl -- Gene discovering / John G. Sgouros and Richard M. Twyman -- series comparability equipment / Christine Orengo -- Amino acid residue conservation / William S.J. Valdar and David T. Jones -- functionality prediction from protein series / Sylvia B. Nagl -- Protein constitution comparability / Ian Sillitoe and Christine Orengo -- Protein constitution classifications / Frances Pearl and Christine Orengo -- Comparative modeling / Andrew C.R. Martin -- Protein constitution prediction / David T. Jones -- From protein constitution to operate / Annabel E. Todd -- From structure-based genome annotation to realizing genes and proteins / Sarah A. Teichmann -- worldwide ways for learning protein-protein interactions / Sarah A. Teichmann -- Predicting the constitution of protein-biomolecular interactions / Richard M. Jackson -- Experimental use of DNA arrays / Paul Kellam and Xiaohui Liu -- Mining gene expression information / Xiaohui Liu and Paul Kellam -- Proteomics / Malcolm P. Weir, Walter P. Blackstock and Richard M. Twyman -- facts managament [sic] of organic info / Nigel J. Martin -- net applied sciences for bioinformatics / Andrew C.R. Martin

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Additional resources for Bioinformatics : genes, proteins, and computers

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E. evolutionarily related sequences, is assessed. 1 Concepts Proteins are essential agents for controlling, effecting and modulating cellular functions and phenotypic behavior. The international genome projects have brought a wealth of protein sequence information from all kingdoms of life and a major goal, now, is to understand how these proteins function. At present the largest international databases contain more than half a million non-identical sequences. Although physical characterization of the biochemical properties of all these proteins is impractical, proteins with similar sequences have diverged from a common ancestral gene and usually have similar structures and functions, with certain caveats (see Chapter 10).

Domain insertion may be preceded by domain duplication events. One of the first mosaic proteins to be studied in detail was tissue plasminogen activator (TPA). TPA converts plasminogen into its active form, plasmin, which dissolves fibrin in blood clots. 7). A special feature of the organization of the TPA gene is that the junctions between acquired domains coincide precisely with exon-intron borders. The evolution of this composite gene thus appears to be a likely result of exon shuffling. The domains present in TPA can also be identified in various arrangements in other proteins.

This is equivalent to restricting the number of insertions/deletions permitted as no insertions can extend beyond the window boundary. Window sizes are often adjusted depending on the differences in lengths between the proteins and also by considering whether the proteins are likely to be close or distant homologs having more extensive insertions. 3c the diagonal lines drawn across the matrix illustrate the position of the window and constrain the optimal pathway identified by the algorithm to be within these boundaries.

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Bioinformatics : genes, proteins, and computers by Christine Orengo, David Jones, Janet Thornton


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