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Bioinformatics - From Genomes to Therapies: The Building - download pdf or read online

By Thomas Lengauer

ISBN-10: 3527312781

ISBN-13: 9783527312788

Once more, Thomas Lengauer has succeeded in making a accomplished and immensely precious bioinformatics source that meets even the excessive criteria of pros within the pharmaceutical and clinical region.

by way of extending the classical software parts of bioinformatics to the newest methods in examining molecular networks and in predicting molecular functionality, this instruction manual serves as a first-stop source for each bioinformatics consumer within the existence sciences. With contributions by way of greater than forty of the world's best bioinformaticians, it's unrivalled when it comes to medical authority and accuracy.

the simplest unmarried details resource to be had, written via pros for execs.

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Read or Download Bioinformatics - From Genomes to Therapies: The Building Blocks: Molecular Sequences and Structures; Volume 2: Getting at the Inner Workings: ... The Holy Grail: Molecular Function PDF

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Extra resources for Bioinformatics - From Genomes to Therapies: The Building Blocks: Molecular Sequences and Structures; Volume 2: Getting at the Inner Workings: ... The Holy Grail: Molecular Function

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They gave the most for receiving the least. Saarbrücken October 2006 Thomas Lengauer XXVII XXIX List of Contributors Bissan Al-Lazikani Asa Ben-Hur Inpharmatica Ltd 1 New Oxford Street London WC1A 1NU UK Colorado State University Department of Computer Science 222 University Services Center 601 South Howes Street Fort Collins, CO 80523 USA USA Russ B. Altman Stanford University Medical Center Department of Genetics 300 Pasteur Drive, Lane L301 Stanford, CA 94305-5120 USA Ron D. Appel Swiss Institute of Bioinformatics CMU - 1, rue Michel Servet 1211 Geneva 4 Switzerland Richard Bonneau New York University Department of Biology/Computer Science Center for Comparative Functional Genomics 100 Washington Square East New York, NY 10003-6688 USA Philip E.

Edited by Thomas Lengauer Copyright c 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ISBN: 978-3-527-31278-8 XXVI Preface many biological insights whose deciphering can be the basis for dramatic scientific and economical success, and is promising to have large impact on society. The book is directed at readers who are interested in how bioinformatics can spur biological and medical innovation towards understanding, diagnosing and curing diseases. The book is designed to be useful to readers with a variety of backgrounds.

4 Library Preprocessing 656 Bioavailability 658 Drug-likeness 659 Molecular Diversity 660 Ligand-based VS 662 Descriptor-based Similarity Measures 664 Bit String Descriptors 665 Feature Trees 666 Molecular Superimposition Approaches 667 Pharmacophore Searches 669 QSARs 670 Other Techniques 672 Postprocessing of Hitlists 672 Data Mining 673 Analysis of the Protein–Ligand Interface 674 Consensus Techniques 675 Visualization 676 Critical Evaluation of Structure-based VS 677 Influence of Parameter Settings 677 Which Library?

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Bioinformatics - From Genomes to Therapies: The Building Blocks: Molecular Sequences and Structures; Volume 2: Getting at the Inner Workings: ... The Holy Grail: Molecular Function by Thomas Lengauer


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