By Prof. Dr. K. Morgenroth (auth.), Prof. Dr. med. Friedrich Kummer (eds.)
The structural adjustments of the bronchial mucosa in bronchial asthma are results of mobile interactions. they seem extra slow than the latter, they usually shape the foundation for the irreversible section of the sensible disease. This underlines the significance of early antiinflammatory remedy. during this context, our curiosity in theophyllin as a modulator of irritation has been evoked lately, supported by means of the newest in vitro and in vivo results.
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The structural alterations of the bronchial mucosa in bronchial asthma are effects of mobile interactions. they seem extra slow than the latter, they usually shape the root for the irreversible part of the practical illness. This underlines the significance of early antiinflammatory remedy. during this context, our curiosity in theophyllin as a modulator of irritation has been evoked lately, supported via the most recent in vitro and in vivo effects.
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Additional info for Asthma: Structural Basis — Theophylline Today / Strukturelle Grundlagen — Theophyllin heute
Whether aberrations of such mechanisms form the basis of T cell reactivity in asthma exist remain unclear. ~ > Q) (j) Fig. 1 Presence and absence of inflammation 27 ever that the coincidence of chronic inflammation and bronchial hyperreactivity within the same individual is like two trains steaming towards each other. The inevitable crash can only be avoided by sufficient regulation of the T cell response possibly by suppressive macrophages which could tum off the inflammation (Fig. 1). References I.
Asthma may thus be defined as a failure to regulate T cell mediated immuno reactivity within the bronchial wall of the hyperreactive individual. This suggestion leaves open the question of where does the failure in T cell regulation occur? There is to date no firm answer to this question. However in our normal individuals the BHR+ subjects showed increased proportions of suppressive macrophages and did not have asthma; whereas in the asthmatic subjects the inflammatory reactions are characterised by reduced proportions of suppressive macrophages!
Burke binding sites for example, what about the adhesion molecules? Did you take them into account? Dr. Poulter: We have not studied adhesion molecules ourselves. But other people certainly have got some data that suggests that adhesion molecules both on the epithelial cells and indeed on the vasculature of the bronchial mucosa are abnormal in asthmatics. And again, these have been shown in studies, demonstrating that both with corticosteroids and again with aminophylline, there was a reversion to normal of adhesion molecules.
Asthma: Structural Basis — Theophylline Today / Strukturelle Grundlagen — Theophyllin heute by Prof. Dr. K. Morgenroth (auth.), Prof. Dr. med. Friedrich Kummer (eds.)