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Download e-book for kindle: Antisense Technology: Applications Part B by Abelson J.N., Simon M.I., Phillips I.M.

By Abelson J.N., Simon M.I., Phillips I.M.

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Extra resources for Antisense Technology: Applications Part B

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Johnson, D. A. Tomalia, and J. R. , Nucleic Acids Res. 24(11), 2176 (1996). 20L. Qin, D. R. Pahud, Y. Ding, A. U. Bielinska, J. F. Kukowska-Latallo,J. R. , and J. S. Bromberg, Hum. Gene Ther. 9(4), 553 (1998). [3] ANTISENSE D N A DELIVERY FOR PROLONGED EFFECTS 37 along with its regulatory sequences, and the recombinant D N A must be packaged with high efficiency into the viral capsid proteins. R etr o viruses Retroviruses have been used primarily because of their high efficiency in delivering genes to dividing cells.

Davis, Antisense Nucleic Acid Drug. Dev. 8(5), 401 (1998). 36 ANTISENSERECEPTORTARGETS [3] Generally, plasmid D N A is considered safer to use than viral vectors, but expression is usually less efficient and shorter lasting. Some improvement has been shown by using different carriers and/or complexing agents, such as liposomes, polyvinylpyrrolidone, or starburst dendrimers. The starburst dendrimers, which are spherical macromolecules composed of repeating polyamidoamine subunits, are quite promising.

Chan, and C. T. Caskey, Proc. Natl. Acad. Sci. A. 93(12), 5731 (1996). 44 It has been used successfully for delivering antisense R N A against a-globin 45 and human immunodeficiency virus (HIV) long terminal repeats, 46 and it is our vector of choice for delivering antisense targeted to the AT1 receptor in cell culture and hypertensive rat models. A A V is a parvovirus, discovered as a contamination of adenoviral stocks. It is a ubiquitous virus (antibodies are present in 85% of the human population in the United States), which has not been linked to any disease.

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Antisense Technology: Applications Part B by Abelson J.N., Simon M.I., Phillips I.M.

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