Sio 2 Books > Nonfiction 11 > Download e-book for iPad: Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and by A. O. Grant (auth.), Prof. Dr. med. Günter Breithardt,

Download e-book for iPad: Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and by A. O. Grant (auth.), Prof. Dr. med. Günter Breithardt,

By A. O. Grant (auth.), Prof. Dr. med. Günter Breithardt, Priv.-Doz. Dr. Martin Borggrefe, Prof. Dr. A. John Camm, Dr. Mohammad Shenasa, Dr. Wilhelm Haverkamp, Dr. Gerhard Hindricks (eds.)

ISBN-10: 3642856241

ISBN-13: 9783642856242

ISBN-10: 3642856268

ISBN-13: 9783642856266

Management and prevention of tachyarrhythmias, specifically of significant ventricular arrhythmias after myocardial infarction, remains to be a massive challenge. Large-scale facts indicates an elevated damage brought about through antiarrhythmic medicines within the presence of natural middle sickness even if they successfully suppress spontaneous arrhythmias. This elevated threat has been associated with their proarrhythmic strength and to attainable interactions by means of ischaemia. even though, the mechanisms during which antiarrhythmic medicinal drugs exert their antiarrhythmic and proarrhythmic activities are nonetheless poorly understood. accordingly, it used to be a time to give an replace at the mechanisms of antiarrhythmic and proarrhythmic motion of gear which act at the electrophysiological houses of the guts. global popular electrophysiologists in addition to clinicians have joint to handle very important subject matters which variety from the impression of antiarrhythmic medications on unmarried channels and on arrhythmia types to the scientific arena.

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Courtney KR (1990) Sodium channel blockers: the size/solubility hypothesis revisited. Mol Pharmacol37: 855 - 859 55. Gruber R, Carmeliet E (1989) The activation gate of the sodium channel controls blockade and deblockade by disopyramide in rabbit Purkinje fibres. Br J Pharmacol 97: 41- 50 56. Schwarz W, Palade PT, Hille B (1977) Local anesthetics: effect of pH on use-dependent block of sodium channels in frog muscle. Biophys J 20: 343 - 368 57. Grant AO, Strauss LJ, Wallace AG, Strauss HC (1982) The influence of pH on the electrophysiological effects of lidocaine in guinea pig ventricular myocardium.

Cahalan MD, Almers W (1979) Interaction between quaternary lidocaine, the sodium channel gates and tetrodotoxin. Biophys J 27: 39 - 56 72. Barber MJ, Wendt DJ, Starmer CF, Grant AD (1992) Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs. J Clin Invest 90:368-381 73- Whalley DW, Wendt DJ, Grant AD (1993) Electrophysiological effects of acute ischemia and their role in the genesis of cardiac arrhythmias. In: Podrid PJ, Kowey PR (ed) Cardiac arrhythmias: mechanism, diagnosis and management.

Khodorov B, Shishkova L, Peganov E, Revenko S (1976) Inhibition of sodium currents in from Ranvier node treated with local anesthetics. Role of slow sodium inactivation. Biochim Biophys Acta 433: 409 - 435 26. Courtney KR (1983) Quantifying antiarrhythmic drug blocking during action potentials in guinea-pig papillary muscle. J Mol Cell Cardiol15: 749 -757 27. Starmer CF, Grant AO, Strauss HC (1984) Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics.

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Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions by A. O. Grant (auth.), Prof. Dr. med. Günter Breithardt, Priv.-Doz. Dr. Martin Borggrefe, Prof. Dr. A. John Camm, Dr. Mohammad Shenasa, Dr. Wilhelm Haverkamp, Dr. Gerhard Hindricks (eds.)


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