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Vincent J. Cristofalo PhD's Annual Review of Gerontology and Geriatrics, Volume 10, PDF

By Vincent J. Cristofalo PhD

ISBN-10: 0826164927

ISBN-13: 9780826164926

This quantity offers a transparent, concise evaluation of the present country of data concerning the biology of getting older ñ serving as either a useful graduate-level textual content and a key reference for practising pros. Over a dozen wonderful individuals probe the newest advancements in our wisdom of why humans age and the way the method works. those authoritative chapters usually are not simply written for biologists ñ yet for gerontologists generally. Marks the 10th anniversary of the once a year evaluate of Gerontology and Geriatrics.

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Extra resources for Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging

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Darlington, G. , & Arnold, A. 1980. Detection of HLA antigens in progeria syndrome fibroblasts. Clinical Genetics, 17, 213-219. , & Gershey, E. 1980. Variation of DNA repair capacity in progeria cells unrelated to growth conditions. Biochemical and Biophysical Research Communications, 97, 347-353. Brown, W. , Kieras, F. , Houck, G. , & Jenkins, E. C. 1985. A comparison of adult and childhood progerias: Werner syndrome and HutchinsonGilford progeria syndrome. In D. Salk, Y. Fujiwara, G. M. ) Werner's syndrome and human aging (pp.

An abnormality of X-ray deoxyribonucleic acid (DNA)-repair capacity in progeria fibroblasts was suggested by Epstein et al. (1973) who detected decreased single-strand rejoining of y-irradiated DNA using alkaline sucrose gradients. , 1980). Defective DNA-repair capacity therefore does not appear to be a consistent marker for progeria, and it seems unlikely to represent a basic genetic defect. A few other isolated reports have suggested abnormalities in progeria. Elevated levels of the blood coagulant tissue factor were reported in both progeria and WS fibroblast cells (Goldstein & Niewiarowski, 1976).

He identified 10 genetic diseases that had the highest number of these features. They included DS, Werner syndrome (WS), Cockayne syndrome (CS), progeria (Hutchinson-Gilford syndrome), ataxia telangectasia, Seip syndrome, cervical lipodysplasia, Klinefelter syndrome, Turner syndrome, and myotonic dystrophy. It is noteworthy that the three chromosomal syndromes analyzed were all selected for inclusion in this list of the top 10 genetic syndromes with features of premature aging. This may suggest that regulatory abnormalities as reflected in the quantitative type of gene dosage differences seen in chromosomal syndromes rather than specific enzymatic defects plan an important role in producing the senescent phenotype.

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Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging by Vincent J. Cristofalo PhD

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