By D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD
A well known team of retina surgeons provides promising new advancements in age-related macular degeneration, with emphasis at the most vital advances long ago 5 years. content material addresses all points of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and remedy; remedy; and destiny instructions. Abundantly illustrated and beautifully geared up, this booklet serves as a great reference and textbook.
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Additional info for Age-related macular degeneration : a comprehensive textbook
103. Smith RS, John SWM, Zabeleta A. The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization. Proc Natl Acad Sci USA. 2000;97:2,1912,195. 104. Majji AB, Hayashi A, Kim HC, et al. Age-related retinal pigment epithelium and Bruch's membrane degeneration in senescence-accelerated mouse. Invest Ophthalmol Vis Sci. 2000;41:3,936-3,942. 105. Kaplan HJ, Leibole MA, Tezel T, et al. Fas ligand (CD95 ligand) controls angiogenesis beneath the retina. Nat Med 1999;5:292-297.
Histopathologic examination of CNV in ARMD shows that while the new vessels grow under the BLD, basal linear deposit is not commonly found in most specimens. This may imply that the basal linear deposit was never present; it was lost in processing; or that the CNV was growing into the layer previously occupied by the basal linear deposit, replacing or removing the deposit. Since the clinical correlate of mounds of basal linear deposit are soft drusen, and since soft drusen are known ocular risk factors for CNV, the latter interpretation seems more likely.
A. Postnatal day 21 (P21) retina exposed to room air. Arrowhead indicates normal intraretinal vessel. B. P21 retina exposed to hyperoxia from P7 to P12, before return to room air. Arrows indicate neovascular tufts extending into the vitreous. Arrowheads mark enlarged intraretinal vessel profiles. GCL, ganglion cell layer; ILM, internal limiting membrane; IPL, inner plexiform layer; V, vitreous (original magnification ×100). (Reprinted with permission from Smith LEH, Wesolowski E, McLellan A, et al.
Age-related macular degeneration : a comprehensive textbook by D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD