By I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins
''...the quantity certainly succeeds total as an in-depth survey of either the biology and the biochemistry of a ubiquitous and astonishingly assorted kin of very complicated enzymes. each team with an curiosity in those proteins should still personal a copy.'' -CELL (July 2003) ''The editors of ABC Proteins: From micro organism to Man have valiantly tried to surround during this quantity the whole scope of study on those proteins, from atomic-resolution constitution to human genetic ailments, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana... What the publication makes seen is that just about all ABC proteins are membrane localized, ATP based, basic energetic transporters...In addition to advances in our realizing of ABC transporter constitution, a number of chapters within the publication additionally describe development that has been made in elcuidating the mechanisms of delivery. the quantity absolutely succeeds total as an in-depth survey of either the biology and the biochemistry of a ubiquitous and astoundingly different relations of very complicated enzymes. each crew with an curiosity in those proteins should still personal a replica. ultimately, this booklet makes a resounding case that many laboratories that will not but suspect it is going to quickly have a way more abiding curiosity in ABC proteins.'' ''...well prepared and incorporated superbly transparent colour photos and figures.'' -E STREAMS (July 2003)
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Additional info for ABC Proteins. From Bacteria to Man
1989). 7A). Only one system has been experimentally characterized, the LolC (IM) LolD (ABC) LolE (IM) system of E. coli. Consequently, it is difficult to generalize to the whole family the properties of this system. Lipoproteins directed to the outer membrane are released from the inner membrane in an ATP-dependent manner through the formation of a complex with LolA, a periplasmic chaperone. , 2000). , 2001). 7. Typical organization of class 3 systems that are not known to be importers. 2 for the representations of membranes and for the IM and ABC domains.
Mol. Gen. Genet. 246, 166–173. M. R. (1987) Cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J. Bacteriol. 169, 3189–3198. , Drobnik, W. and Schmitz, G. (2000) Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem. Biophys. Res. Commun. 273, 532–538. , Trowsdale, J. J. (1999) Antigen presentation: TAP dances with ATP. Curr. Biol. 9, R820–R824. , Kieser, T. and Vijgenboom, E. (2000) The ram-dependence of Streptomyces lividans differentiation is bypassed by copper.
Melanogaster but none in S. cerevisiae. Six of the A. thaliana proteins have an IM-ABC type organization. The DRI family involved in drug resistance, and bacteriocin and lantibiotic immunity This family is composed of systems having the same global organization as those of the DRA family. 1). No significant similarity could be detected between IM proteins of these two families. DRI family systems are found in prokaryotes and some of these are involved in antibiotic resistance and in bacteriocin and lantibiotic immunity.
ABC Proteins. From Bacteria to Man by I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins